Results from the “Reproducibility Project: Cancer Biology”

[Excerpts are taken from the article “Investigating the replicability of preclinical cancer biology” by Errington et al., published in eLife.]

“Large-scale replication studies in the social and behavioral sciences provide evidence of replicability challenges (Camerer et al., 2016; Camerer et al., 2018; Ebersole et al., 2016; Ebersole et al., 2020; Klein et al., 2014; Klein et al., 2018; Open Science Collaboration, 2015).”

“In psychology, across 307 systematic replications and multisite replications, 64% reported statistically significant evidence in the same direction and effect sizes 68% as large as the original experiments (Nosek et al., 2021).”

“In the biomedical sciences, the ALS Therapy Development Institute observed no effectiveness of more than 100 potential drugs in a mouse model in which prior research reported effectiveness in slowing down disease, and eight of those compounds were tried and failed in clinical trials costing millions and involving thousands of participants (Perrin, 2014).”

“Of 12 replications of preclinical spinal cord injury research in the FORE-SCI program, only two clearly replicated the original findings – one under constrained conditions of the injury and the other much more weakly than the original (Steward et al., 2012).”

“And, in cancer biology and related fields, two drug companies (Bayer and Amgen) reported failures to replicate findings from promising studies that could have led to new therapies (Prinz et al., 2011; Begley and Ellis, 2012). Their success rates (25% for the Bayer report, and 11% for the Amgen report) provided disquieting initial evidence that preclinical research may be much less replicable than recognized.”

“In the Reproducibility Project: Cancer Biology, we sought to acquire evidence about the replicability of preclinical research in cancer biology by repeating selected experiments from 53 high-impact papers published in 2010, 2011, and 2012 (Errington et al., 2014). We describe in a companion paper (Errington et al., 2021b) the challenges we encountered while repeating these experiments. … These challenges meant that we only completed 50 of the 193 experiments (26%) we planned to repeat. The 50 experiments that we were able to complete included a total of 158 effects that could be compared with the same effects in the original paper.”

“There is no single method for assessing the success or failure of replication attempts (Mathur and VanderWeele, 2019; Open Science Collaboration, 2015; Valentine et al., 2011), so we used seven different methods to compare the effect reported in the original paper and the effect observed in the replication attempt…”

“…136 of the 158 effects (86%) reported in the original papers were positive effects – the original authors interpreted their data as showing that a relationship between variables existed or that an intervention had an impact on the biological system being studied. The other 22 (14%) were null effects – the original authors interpreted their data as not showing evidence for a meaningful relationship or impact of an intervention.”

“Furthermore, 117 of the effects reported in the original papers (74%) were supported by a numerical result (such as graphs of quantified data or statistical tests), and 41 (26%) were supported by a representative image or similar. For effects where the original paper reported a numerical result for a positive effect, it was possible to use all seven methods of comparison. However, for cases where the original paper relied on a representative image (without a numerical result) as evidence for a positive effect, or when the original paper reported a null effect, it was not possible to use all seven methods.”

Summarizing replications across five criteria

“To provide an overall picture, we combined the replication rates by five of these criteria, selecting criteria that could be meaningfully applied to both positive and null effects … The five criteria were: (i) direction and statistical significance (p < 0.05); (ii) original effect size in replication 95% confidence interval; (iii) replication effect size in original 95% confidence interval; (iv) replication effect size in original 95% prediction interval; (v) meta-analysis combining original and replication effect sizes is statistically significant (p < 0.05).”

FIGURE 6. Investigating the replicability of preclinical cancer biology

“For replications of original positive effects, 13 of 97 (13%) replications succeeded on all five criteria, 15 succeeded on four, 11 succeeded on three, 22 failed on three, 15 failed on four, and 21 (22%) failed on all five (… Figure 6).”

“For original null effects, 7 of 15 (47%) replications succeeded on all five criteria, 2 succeeded on four, 3 succeeded on three, 0 failed on three, 2 failed on four, and 1 (7%) failed on all five.”

“… Combining positive and null effects, 51 of 112 (46%) replications succeeded on more criteria than they failed, and 61 (54%) replications failed on more criteria than they succeeded.”

“We explored five candidate moderators of replication success and did not find strong evidence to indicate that any of them account for variation in replication rates we observed in our sample. The clearest indicator of replication success was that smaller effects were less likely to replicate than larger effects … Research into replicability in other disciplines has also found that findings with stronger initial evidence (such as larger effect sizes and/or smaller p-values) is more likely to replicate (Nosek et al., 2021; Open Science Collaboration, 2015).”

“The present study provides substantial evidence about the replicability of findings in a sample of high-impact papers published in the field of cancer biology in 2010, 2011, and 2012. The evidence suggests that replicability is lower than one might expect of the published literature. Causes of non-replicability could be due to factors in conducting and reporting the original research, conducting the replication experiments, or the complexity of the phenomena being studied. The present evidence cannot parse between these possibilities…”

“Stakeholders from across the research community have been raising concerns and generating evidence about dysfunctional incentives and research practices that could slow the pace of discovery. This paper is just one contribution to the community’s self-critical examination of its own practices.”

“Science pursuing and exposing its own flaws is just science being science. Science is trustworthy because it does not trust itself. Science earns that trustworthiness through publicly, transparently, and continuously seeking out and eradicating error in its own culture, methods, and findings. Increasing awareness and evidence of the deleterious effects of reward structures and research practices will spur one of science’s greatest strengths, self-correction.”

To read the full article, click here.

References

Begley CG, Ellis LM. 2012. Drug development: Raise standards for preclinical cancer research. Nature 483:531–533.

Camerer C. F, Dreber A, Forsell E, Ho TH, Huber J, Johannesson M, Kirchler M, Almenberg J, Altmejd A, Chan T, Heikensten E, Holzmeister F, Imai T, Isaksson S, Nave G, Pfeiffer T, Razen M, Wu H. 2016. Evaluating replicability of laboratory experiments in economics. Science 351: 1433–1436.

Camerer CF, Dreber A, Holzmeister F, Ho T-H, Huber J, Johannesson M, Kirchler M, Nave G, Nosek BA, Pfeiffer T, Altmejd A, Buttrick N, Chan T, Chen Y, Forsell E, Gampa A, Heikensten E, Hummer L, Imai T, Isaksson S, et al. 2018. Evaluating the replicability of social science experiments in Nature and Science between 2010 and 2015. Nature Human Behaviour 2: 637–644.

Ebersole CR, Mathur MB, Baranski E, Bart-Plange D-J, Buttrick NR, Chartier CR, Corker KS, Corley M, Hartshorne JK, IJzerman H, Lazarević LB, Rabagliati H, Ropovik I, Aczel B, Aeschbach LF, Andrighetto L, Arnal JD, Arrow H, Babincak P, Bakos BE, et al. 2020. Many Labs 5: Testing Pre-Data-Collection Peer Review as an Intervention to Increase Replicability. Advances in Methods and Practices in Psychological Science 3:309–331.

Ebersole CR, Atherton OE, Belanger AL, Skulborstad HM, Allen JM, Banks JB, Baranski E, Bernstein MJ, Bonfiglio DBV, Boucher L, Brown ER, Budiman NI, Cairo AH, Capaldi CA, Chartier CR, Chung JM, Cicero DC, Coleman JA, Conway JG, Davis WE, et al. 2016. Many Labs 3: Evaluating participant pool quality across the academic semester via replication. Journal of Experimental Social Psychology 67: 68–82.

Errington TM, Iorns E, Gunn W, Tan FE, Lomax J, Nosek BA. 2014. An open investigation of the reproducibility of cancer biology research. eLife 3: e04333.

Errington TM, Denis A, Perfito N, Iorns E, Nosek BA. 2021b. Challenges for assessing replicability in preclinical cancer biology. eLife 10: e67995.

Klein RA, Ratliff KA, Vianello M, Adams RB, Bahník Š, Bernstein MJ, Bocian K, Brandt MJ, Brooks B, Brumbaugh CC, Cemalcilar Z, Chandler J, Cheong W, Davis WE, Devos T, Eisner M, Frankowska N, Furrow D, Galliani EM, Nosek BA. 2014. Investigating Variation in Replicability: A “Many Labs” Replication Project. Social Psychology 45: 142–152.

Klein RA, Vianello M, Hasselman F, Adams BG, Adams RB, Alper S, Aveyard M, Axt JR, Babalola MT, Bahník Š, Batra R, Berkics M, Bernstein MJ, Berry DR, Bialobrzeska O, Binan ED, Bocian K, Brandt MJ, Busching R, Rédei AC, et al. 2018. Many Labs 2: Investigating Variation in Replicability Across Samples and Settings. Advances in Methods and Practices in Psychological Science 1: 443–490.

Mathur MB, VanderWeele TJ. 2019. Challenges and suggestions for defining replication “success” when effects may be heterogeneous: Comment on Hedges and Schauer (2019). Psychological Methods 24: 571–575.

Nosek BA, Hardwicke TE, Moshontz H, Allard A, Corker KS, Dreber A, Fidler F, Hilgard J, Struhl MK, Nuijten MB, Rohrer JM, Romero F, Scheel AM, Scherer LD, Schönbrodt FD, Vazire S. 2021. Replicability, Robustness, and Reproducibility in Psychological Science. Annual Review of Psychology 73: 114157.

Open Science Collaboration. 2015. Estimating the reproducibility of psychological science. Science 349:aac4716.

Perrin S. 2014. Preclinical research: Make mouse studies work. Nature 507: 423–425.

Prinz F, Schlange T, Asadullah K. 2011. Believe it or not: how much can we rely on published data on potential drug targets? Nature Reviews Drug Discovery 10: 712.

Steward O, Popovich PG, Dietrich WD, Kleitman N. 2012. Replication and reproducibility in spinal cord injury research. Experimental Neurology 233: 597–605.

Valentine JC, Biglan A, Boruch RF, Castro FG, Collins LM, Flay BR, Kellam S, Mościcki EK, Schinke SP. 2011. Replication in prevention science. Prevention Science 12: 103–117.

Want to Be In on the Final Stage of the SCORE Project? A Call for Collaborators from COS

The SCORE project is entering its final phase of conducting reproductions (repeating the original analysis with original data) and replications (testing the same claim with new data) on a stratified random sample of claims from papers across the social-behavioral sciences.

Here is your opportunity to contribute to these efforts for non-human subjects research (non-HSR) work, meaning projects that use existing data and do not require any additional IRB review steps. We’d love to have your collaboration! 

This spreadsheet contains all of the non-HSR projects available, with different tabs corresponding to different project categories.

This announcement outlines the different project categories at a high level. More details can be found in this explanation of our terminology, as well as specific instructions tailored for replication projects (DARs) and reproduction projects.

There are six project categories, depending on two factors: the type of data used and the number of claims selected.

Data types: (i) Datasets provided by the author (PBR/ADR), (ii) Original observations reconstructed from the underlying data sources (SDR), and (iii) New observations that were not already analyzed in the original article (DAR)

Number of claims: (i) Just one claim per article (singe-trace) and (ii) A minimum of five claims per article (bushel), unless fewer are available.

We have identified the most feasible projects in separate tabs. We highly encourage collaborators to review these projects first. Projects are highly feasible if we already have the data in hand, or if we’ve identified the data sources as relatively simple to obtain.

Finally, we have included a column in each tab labeled ‘high_incentive,’ coded as yes or no. If a project is coded as ‘yes,’ it means the payment for completing the project will be higher than other projects from the same category. The full set of payments can be found here.

Your next steps

Select one or more projects you anticipate being able to complete, by adding your name in the respective signup cell. Please consider whether you’ll be able to obtain the necessary materials before signing up.

After signing up but before submitting the commitment form, please confirm you can access all of the necessary materials to complete the project. If this requires author data that COS does not currently have but that you think could be made available, please do not reach out to the authors directly. Instead, please contact COS for assistance in getting in touch with the authors.

After you have obtained all of the materials necessary to begin your project, please complete the commitment form linked in the spreadsheet, after which someone from COS will provide you access to an OSF project and preregistration form.

Please keep the following privacy statement in mind as you complete these steps: Other teams are making predictions about the outcomes of many different studies, not knowing which studies have been selected for replication/reproduction. As a consequence, the success of this project requires full confidentiality of the research process. This includes privacy about which studies have been selected for replication and all aspects of the discussion about these replication designs.

Et tu, Finance?

[Excerpts are taken from the article “The hidden ‘replication crisis’ of finance”, by Robin Wigglesworth, published at Financial Times online.]

“It may sound like a low-budget Blade Runner rip-off, but over the past decade the scientific world has been gripped by a “replication crisis” — the findings of many seminal studies cannot be repeated, with huge implications. Is investing suffering from something similar?”

“That is the incendiary argument of Campbell Harvey, professor of finance at Duke University. He reckons that at least half of the 400 supposedly market-beating strategies identified in top financial journals over the years are bogus. Worse, he worries that many fellow academics are in denial about this.”

“Harvey is not some obscure outsider or performative contrarian attempting to gain attention through needless controversy. He is the former editor of the Journal of Finance, a former president of the American Finance Association, and an adviser to investment firms like Research Affiliates and Man Group. He has written more than 150 papers on finance, several of which have won prestigious prizes.”

“To understand what the ‘replication crisis’ is, how it has happened and its implications for finance, it helps to start at its broader genesis. In 2005, Stanford medical professor John Ioannidis published a bombshell essay titled “Why Most Published Research Findings Are False ”, which noted that the results of many medical research papers could not be replicated by other researchers. Subsequently, several other fields have turned a harsh eye on themselves and come to similar conclusions. The heart of the issue is a phenomenon that researchers call “p-hacking”.”

“P-hacking is when researchers overtly or subconsciously twist the data to find a superficially compelling but ultimately spurious relationship between variables. It can be done by cherry-picking what metrics to measure, or subtly changing the time period used. Just because something is narrowly statistically significant, does not mean it is actually meaningful. A trading strategy that looks golden on paper might turn up nothing but lumps of coal when actually implemented.”

“AQR, a prominent quant investment group, is also sceptical that there are hundreds of durable and successful factors that can help investors beat markets, but argues that the “replication crisis” brouhaha is overdone. Earlier this year it published a paper that concluded that not only could the majority of the studies it examined be replicated, they still worked “out of sample” — in actual live trading —and were actually further corroborated by international data.”

“Harvey is unconvinced by the riposte, and will square up to the AQR paper’s authors at the American Finance Association’s annual meeting in early January. “That’s going to be a very interesting discussion,” he promises.”

To read the full article, click here.

IREE Scores a Top Score in TOP Factor

The International Journal for Re-Views in Empirical Economics (IREE) is the only journal in economics solely dedicated to publishing replications. Recently, IREE was evaluated by TOP Factor. TOP Factor is an initiative launched by the Center for Open Science to assess journals according to “a values-aligned rating of journal policies as a counterweight to metrics that incentivize journals to publish exciting results regardless of credibility” (see here). The assessment of IREE‘s journal policies resulted in a journal score of 13 points. This puts IREE in 4th place among all 136 economic journals rated by TOP Factor, ahead of the American Economic Review, Econometrica, Plos One, and Science.

TOP Factor provides an alternative to metrics such as the journal impact factor (JIF). It constitutes a first step towards evaluating journals based on their quality of process and implementation of scholarly values. “Too often, journals are compared using metrics that have nothing to do with their quality,” says Evan Mayo-Wilson, Associate Professor in the Department of Epidemiology and Biostatistics at Indiana University School of Public Health-Bloomington. “The TOP Factor measures something that matters. It compares journals based on whether they require transparency and methods that help reveal the credibility of research findings.” (see COS announcement of TOP factor, 2020).

TOP Factor is based on the Transparency and Openness Promotion (TOP) Guidelines, a framework of eight standards that summarize behaviors that can improve transparency and reproducibility of research such as transparency of data, materials, code, and research design, preregistration, and replication.

Editor Martina Grunow announced that she was very pleased with this rating, as TOP Factor reflects exactly what IREE stands for: reducing the publication bias towards literally incredible and non-reproducible results and the resulting “publish-or-perish” culture. Like TOP Factor, IREE promotes the reproducibility and transparency of published results and scientific discourse in economics based on high-quality and credible research results.

AIMOS 2021 Is Happening. You Can Be a Part of It.

Registration is now open for the 3rd annual Association for Interdisciplinary Metaresearch and Open Science Conference – aimos 2021 to be held Tuesday 30 Nov – Friday 3 Dec 2021! 

aimos 2021 will offer the opportunity for researchers from many fields – psychology, ecology, medicine, biology, economics, statistics, philosophy, social studies of science, and more, to talk about how we do research, and how we can improve it.  

This year’s conference includes plenary lectures opened by Professor Brian Nosek reflecting on the last 10 years of metaresearch, and closed by Dr. Rose O’Dea on the future of metaresearch. The program will also explore other areas of metaresearch including notable plenary lectures from Prof. Sarah de Rijcke and Dr Julia Rohrer.

In addition to invited speaker sessions, aimos 2021 will open submissions for: discussions about norms, practices, and cultures with science and scholarship more broadly; learning and development, through practical skills workshops in open science (e.g., R, lab notebooks, pre-registration); and getting things done in hackathons.

Visit the Conference website to check out the schedule and speakers, submit your proposal and express your interest in attending!

Let’s connect at aimos 2021!

Fudging Data About Dishonesty

[Excerpts are taken from the blog “Evidence of Fraud in an Influential Field Experiment About Dishonesty” posted by Uri Simonsohn, Joe Simmons, Leif Nelson and anonymous researchers at Data Colada]

“This post is co-authored with a team of researchers who have chosen to remain anonymous. They uncovered most of the evidence reported in this post.”

“In 2012, Shu, Mazar, Gino, Ariely, and Bazerman published a three-study paper in PNAS reporting that dishonesty can be reduced by asking people to sign a statement of honest intent before providing information (i.e., at the top of a document) rather than after providing information (i.e., at the bottom of a document).”

“In 2020, Kristal, Whillans, and the five original authors published a follow-up in PNAS entitled, “Signing at the beginning versus at the end does not decrease dishonesty”.

“Our focus here is on Study 3 in the 2012 paper, a field experiment (N = 13,488) conducted by an auto insurance company … under the supervision of the fourth author. Customers were asked to report the current odometer reading of up to four cars covered by their policy.”

“The authors of the 2020 paper did not attempt to replicate that field experiment, but they did discover an anomaly in the data…our story really starts from here, thanks to the authors of the 2020 paper, who posted the data of their replication attempts and the data from the original 2012 paper.”

“A team of anonymous researchers downloaded it, and discovered … very strong evidence that the data were fabricated.”

“Let’s start by describing the data file. Below is a screenshot of the first 12 observations:”

“You can see variables representing the experimental condition, a masked policy number, and two sets of mileages for up to four cars. The “baseline_car[x]” columns contain the mileage that had been previously reported for the vehicle x (at Time 1), and the “update_car[x]” columns show the mileage reported on the form that was used in this experiment (at Time 2).”

“On to the anomalies.”

Anomaly #1: Implausible Distribution of Miles Driven

“Let’s first think about what the distribution of miles driven should look like…we might expect…some people drive a whole lot, some people drive very little, and most people drive a moderate amount.”

“As noted by the authors of the 2012 paper, it is unknown how much time elapsed between the baseline period (Time 1) and their experiment (Time 2), and it was reportedly different for different customers. … It is therefore hard to know what the distribution of miles driven should look like in those data.”

“It is not hard, however, to know what it should not look like. It should not look like this:”

“First, it is visually and statistically (p=.84) indistinguishable from a uniform distribution ranging from 0 miles to 50,000 miles. Think about what that means. Between Time 1 and Time 2, just as many people drove 40,000 miles as drove 20,000 as drove 10,000 as drove 1,000 as drove 500 miles, etc. This is not what real data look like, and we can’t think of a plausible benign explanation for it.”

“Second, there is some weird stuff happening with rounding…”

Anomaly #2: No Rounded Mileages At Time 2

“The mileages reported in this experiment … are what people wrote down on a piece of paper. And when real people report large numbers by hand, they tend to round them.”

“Of course, in this case some customers may have looked at their odometer and reported exactly what it displayed. But undoubtedly many would have ballparked it and reported a round number.”

“In fact, as we are about to show you, in the baseline (Time 1) data, there are lots of rounded values.”

“But random number generators don’t round. And so if, as we suspect, the experimental (Time 2) data were generated with the aid of a random number generator (like RANDBETWEEN(0,50000)), the Time 2 mileage data would not be rounded.”

“The figure shows that while multiples of 1,000 and 100 were disproportionately common in the Time 1 data, they weren’t more common than other numbers in the Time 2 data.”

“These data are consistent with the hypothesis that a random number generator was used to create the Time 2 data.”

“In the next section we will see that even the Time 1 data were tampered with.”

Interlude: Calibri and Cambria

“Perhaps the most peculiar feature of the dataset is the fact that the baseline data for Car #1 in the posted Excel file appears in two different fonts. Specifically, half of the data in that column are printed in Calibri, and half are printed in Cambria.”

“The analyses we have performed on these two fonts provide evidence of a rather specific form of data tampering.”

“We believe the dataset began with the observations in Calibri font. Those were then duplicated using Cambria font. In that process, a random number from 0 to 1,000 (e.g., RANDBETWEEN(0,1000)) was added to the baseline (Time 1) mileage of each car, perhaps to mask the duplication.”

“In the next two sections, we review the evidence for this particular form of data tampering.”

Anomaly #3: Near-Duplicate Calibri and Cambria Observations

“…the baseline mileages for Car #1 appear in Calibri font for 6,744 customers in the dataset and Cambria font for 6,744 customers in the dataset. So exactly half are in one font, and half are in the other. For the other three cars, there is an odd number of observations, such that the split between Cambria and Calibri is off by exactly one (e.g., there are 2,825 Calibri rows and 2,824 Cambria rows for Car #2).”

“… each observation in Calibri tends to match an observation in Cambria.”

“To understand what we mean by “match” take a look at these two customers:”

“The top customer has a “baseline_car1” mileage written in Calibri, whereas the bottom’s is written in Cambria. For all four cars, these two customers have extremely similar baseline mileages.”

“Indeed, in all four cases, the Cambria’s baseline mileage is (1) greater than the Calibri mileage, and (2) within 1,000 miles of the Calibri mileage. Before the experiment, these two customers were like driving twins.”

“Obviously, if this were the only pair of driving twins in a dataset of more than 13,000 observations, it would not be worth commenting on. But it is not the only pair.”

“There are 22 four-car Calibri customers in the dataset. All of them have a Cambria driving twin…there are twins throughout the data, and you can easily identify them for three-car, two-car, and unusual one-car customers, too.”

“To see a fuller picture of just how similar these Calibri and Cambria customers are, take a look at Figure 5, which shows the cumulative distributions of baseline miles for Car #1 and Car #4.”

“Within each panel, there are two lines, one for the Calibri distribution and one for the Cambria distribution. The lines are so on top of each other that it is easy to miss the fact that there are two of them:”

Anomaly #4: No Rounding in Cambria Observations

“As mentioned above, we believe that a random number between 0 and 1,000 was added to the Calibri baseline mileages to generate the Cambria baseline mileages. And as we have seen before, this process would predict that the Calibri mileages are rounded, but that the Cambria mileages are not.”

“This is indeed what we observe:”

Conclusion

“The evidence presented in this post indicates that the data underwent at least two forms of fabrication: (1) many Time 1 data points were duplicated and then slightly altered (using a random number generator) to create additional observations, and (2) all of the Time 2 data were created using a random number generator that capped miles driven, the key dependent variable, at 50,000 miles.”

“We have worked on enough fraud cases in the last decade to know that scientific fraud is more common than is convenient to believe… There will never be a perfect solution, but there is an obvious step to take: Data should be posted.” 

“The fabrication in this paper was discovered because the data were posted. If more data were posted, fraud would be easier to catch. And if fraud is easier to catch, some potential fraudsters may be more reluctant to do it. … All of our journals should require data posting.”

“Until that day comes, all of us have a role to play. As authors (and co-authors), we should always make all of our data publicly available. And as editors and reviewers, we can ask for data during the review process, or turn down requests to review papers that do not make their data available.”

“A field that ignores the problem of fraud, or pretends that it does not exist, risks losing its credibility. And deservedly so.”

To read the full blog, click here.

Early Bird Discount for Tickets to (Virtual) Metascience 2021 Expires July 31st!

Early bird tickets are still available for Metascience 2021 at the discounted rate of $10 USD. To check out the conference, go here. For tickets, go here.

Replication Leads to High Profile Retraction

[Excerpts are taken from the article “Retracted: Risk Management in Financial Institutions” “ by Adriano Rampini, S. Viswanathan, and Guillaume Vuillemey, published in the Journal of Finance]

“The authors hereby retract the above article, published in print in the April 2020 issue of The Journal of Finance. A replication study finds that the replication code provided in the supplementary information section of the article does not reproduce some of the central findings reported in the article.”

“Upon reexamination of the work, the authors confirmed that the replication code does not fully reproduce the published results and were unable to provide revised code that does. Therefore, the authors conclude that the published results are not reliable and that the responsible course of action is to retract the article and return the Brattle Group Distinguished Paper Prize that the article received.”

To read the article, click here. 

Last Call for Metascience 2021 Submissions

FROM THE METASCIENCE 2021 ORGANIZING COMMITTEE:

You’re invited to submit an event or lightning talk proposal to the Metascience 2021 Conference by this Wednesday, June 30 to help contribute to the enrichment of attendees’ perspectives of the field of metascience. Take a moment to view full submission criteria and tips at metascience2021.org/submit.

Metascience 2021 will explore the themes of metascience and the scientific process through a global, interdisciplinary, cross-sector lens. This year’s virtual format takes place across time zones at peak hours to promote voices in metascience across regions. 

Thank you for considering this opportunity to be a part of the global metascience discussion to advance scientific progress.